ea0077p43 | Metabolism, Obesity and Diabetes | SFEBES2021
Nikolaou Nikolaos
, Arvaniti Anastasia
, Sanna Fabio
, Saikali Michael
, da Conceicao Ismael
, Dempster Niall
, Gathercole Laura
, Cummins Carolyn
, Tomlinson Jeremy
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from simple intrahepatic lipid accumulation to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). 5β-reductase (AKR1D1) is a liver enzyme that catalyses a fundamental step in bile acid (BA) synthesis. Both BAs and BA intermediates are established as potent regulators of metabolic and proliferative phenotype. We have hypothesised that AKR1D1 plays a crucial regulatory role in NAFLD and HCC. Hu...